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Upstream Bio, Inc. (UPB) Stock Grade

UPB · Healthcare

C
Grade updated: September 29, 2026
Computed by the GradeMyInvestments scoring model from revenue growth, profitability, balance-sheet strength, and analyst targets.
Market Cap
$288.4M
P/E Ratio
—
Revenue Growth (YoY)
+20.4%
Net Margin
-5026.0%
Return on Equity
—
Dividend Yield
None

About Upstream Bio, Inc.'s fundamentals

Upstream Bio is a biotechnology company with a market capitalization of $288.4 million that is experiencing strong revenue growth at 20.4% year-over-year. However, the company is currently unprofitable, reporting a net loss in its latest annual statement with a net margin of -5026.0%, indicating substantial operating losses relative to its revenue base. The company does not pay a dividend and lacks positive return on equity metrics, which is typical for early-stage biotech firms still in development phases. Investors should note that profitability metrics and traditional valuation ratios like P/E ratio are not meaningful given the company's current loss-making status.

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